An insular view of anxiety.

NEURONAL ACTIVATION AND PERIPHERAL PHYSIOLOGY REACTION PATTERN DUE TO SPECIFIC PHOBIA View project Changes in chill responds after left anterior insular lesion View project

Anterior insular cortex mediates bodily sensibility and social anxiety.

Studies in psychiatry and cognitive neuroscience have reported an important relationship between individual interoceptive accuracy and anxiety level. This indicates that greater attention to one's bodily state may contribute to the development of intense negative emotions and anxiety disorders. We hypothesized that reactivity in the anterior insular cortex underlies the intensity of interocepti...

Individual differences in insular sensitivity during loss anticipation predict avoidance learning.

The anterior insula has been implicated in both the experience and the anticipation of negative outcomes. Although individual differences in insular sensitivity have been associated with self-report measures of chronic anxiety, previous research has not examined whether individual differences in insular sensitivity predict learning to avoid aversive stimuli. In the present study, insular sensit...

Morphology of Human Insula in Iranian Population and its Relationship with Sex, Age, and Handedness: an Imaging Anatomical Study

Background and Aim: Topography of the human insula has occasionally been studied in different populations. The purpose of this study was to evaluate the morphology of human insula in Iranian population and its relationship with sex, age, and handedness via magnetic resonance imaging. Methods and Materials/Patients: In our study, 380 normal magnetic resonance imaging were enrolled. The number...

Insular Volume Reduction in Patients with Social Anxiety Disorder

Despite the fact that social anxiety disorder (SAD) is highly prevalent, there have been only a few structural imaging studies. Moreover, most of them reported about a volume reduction in amygdale, which plays a key role in the neural function of SAD. Insula is another region of interest. Its hyperactivity in regard to processing negative emotional information or interoceptive awareness has bee...